Mannose‐Binding Lectin Gene Polymorphisms as a Susceptibility Factor for Chronic Necrotizing Pulmonary Aspergillosis

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Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis.

It was investigated whether a deficiency of mannose-binding lectin (MBL), which binds Aspergillus species avidly in vitro, could account for chronic necrotizing pulmonary aspergillosis (CNPA), which is seen most commonly in nonimmunocompromised patients. Blood samples were obtained from 11 patients (10 white) with CNPA and were compared with blood samples from 82 white control subjects. MBL hap...

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Chronic necrotizing pulmonary aspergillosis.

Chronic necrotizing pulmonary aspergillosis is not common and usually involves mildly immunosuppressed patients. We present a case of a 58-year-old man with a history of mining-related pneumoconiosis and corticosteroid therapy who developed bilateral pulmonary infiltrates and subsequent cavitation. The patient was treated at first as having community-acquired pneumonia and was only belatedly di...

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Chronic necrotizing pulmonary aspergillosis.

INTRODUCTION Chronic necrotizing pulmonary aspergillosis (CNPA) is a cavitary, infectious process of lung parenchyma with slow progressive course. Vascular invasion and dissemination to other organs are unusual. CASE REPORT We presented a 25-year old man with bilineal acute leukaemia who developed pulmonary and systemic symptoms. Chest CT showed nodular consolidations and cavitary lesions in ...

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Chronic necrotizing pulmonary aspergillosis or invasive pulmonary aspergillosis.

Affiliations: Dr. Silvestri is affiliated with Presidio Ospedaliero. Dr. van Saene is affiliated with the University of Liverpool. Dr. de la Cal is affiliated with University Hospital. Dr. De Gaudio is affiliated with the University of Florence. Financial/nonfinancial disclosures: The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizati...

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Necrotizing pulmonary aspergillosis.

Necrotizing or invasive aspergillary infection of the lungs has previously been considered a rare condition affecting only the debilitated or seriously ill. Four patients with necrotizing pulmonary aspergillosis are described, and the mycological and histopathological findings are discussed. The diagnosis in the first patient was not made until necropsy, following death from fulminating pulmona...

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ژورنال

عنوان ژورنال: The Journal of Infectious Diseases

سال: 2001

ISSN: 0022-1899,1537-6613

DOI: 10.1086/322791